Introduction; F.Cecconi, M. D'Amelio 1. Physiological and Pathological Role of Apoptosis; V. Cavallucci, M. D'Amelio 2. Apoptosome structure and regulation; E. Ferraro, C. Fuoco, F. Strapazzon, F. Cecconi 3. Chemical regulation of the apoptosome: new alternative treatments for cancer; K. Cain 4. Molecules that bind a central protein component of the apoptosome, Apaf-1,and modulate its activity; L. Mondragón, M. Orzáez, A. Gortat, M. Sancho, A. Messeguer, M.J. Vicent and E. Pérez-Payá 5. Regulation of cell death and survival by RNA interference - The roles of miRNA and siRNA; P. Lingor 6. Beneficial role of taurine against myocardial apoptosis during ischemic injury; T. Ito, S .W. Schaffer, J. Azuma 7. BAG3 protein: role in some neoplastic cell types and identification as a candidate target for therapy; M. Pascale, A. Rosati, M. Festa, A. Basile, M. d'Avenia, A. Falco, G. Torino and M.C. Turco 8. Targeting Survivin in cancer therapy: Pre-clinical studies; M. Pennati, M. Folini and N. Zaffaroni 9. Hsp70 and Hsp27: Emerging Targets in Cancer Therapy; A.L. Rérole, A.L. Joly, D. Thuringer and C. Garrido 10. Role of the RNA-binding protein HuR in Apoptosis and Apoptosome Function; Y. Kuwano, I. Gallouzi, and M. Gorospe 11. Acetylcholinesterase as a Pharmacological Target in Cancer Research; S.E. Park, Y.H. Yoo 12. Putative role of HCA66, a new Apaf-1 interacting protein, in the physiopathology of NF1 microdeletion syndrome patients; P. Rigou, A. Faye and J.L. Poyet 13. Cristae remodeling andmitochondrial fragmentation: a checkpoint for cytochrome c release and apoptosis?; L. Scorrano 14. Apoptosome pharmacological manipulation: from current developments in the laboratory to clinical implications; M. D'Amelio and F.Cecconi 15. The Therapeutic Role of Taurine in Ischaemia-Reperfusion Injury; R. Kingston 16. Targeting survivin in cancer therapy: Clinical considerations; T. Tsuruma, H. Kameshima, Y. Iwayama, T. Torigoe, Y. Hirohashi, N. Sato, K. Hirata