Introduction.- History of PE.- Anatomy And Physiology Of Ejaculation.- Epidemiology Of Premature Ejaculation.- Taxonomy of ejaculatory disorders and definitions of Premature Ejaculation.- Pathophysiology Of Lifelong Premature Ejaculation.-Pathophysiology Of Acquired Premature Ejaculation.- Risks factors in Premature Ejaculation: The intrapsychic risk factor.-Risks factors in Premature Ejaculation: The genetic risk factor.- Twin Studies and Quantitative Genetics in Premature Ejaculation Research.- Risks factors in Premature Ejaculation: The relational risk factor.- Endocrine control of ejaculation.-Risks factors in Premature Ejaculation: The urological risk factor.- Risks factors in Premature Ejaculation: The neurological risk factor and the local hypersensitivity.- Risks factors in Premature Ejaculation: Experimental psychology in the evaluation of PE.- Patient Reported Outcomes Used in the Assessment of Premature Ejaculation.- Treatment Of Premature Ejaculation With Cognitive Behavioural Therapy.- The psychodynamic approach to Premature Ejaculation.-Treatment Of Premature Ejaculation With Selective Serotonin Re-Uptake Inhibitors (SSRIs).- Treatment Of Premature Ejaculation With Dapoxetine.- Use of local anaesthetics in the treatment of premature ejaculation.- Secondary PE.- Treatment Of Premature Ejaculation And Comorbid Endocrine and Metabolic diseases.-Complementary, surgical, and experimental modalities for management of premature ejaculation.- From Diagnosis to Treatment: The Office Management of Premature Ejaculation.- Clinical Trial Designs For Premature Ejaculation Observational, Intervention and Intervention Preference Studies.- Future Treatments Of Premature Ejaculation.- Appendix: psychometric tools for premature ejaculation and related erectile dysfunction.