Preface... Table of Contents... Contributing Authors... Part I Isolation of Progenitor Cells 1. Long-Term Culture of Mouse Fetal Hepatic Stem/Progenitor Cells Atsunori Tsuchiya and Shuji Terai 2. Isolation of Bipotential Liver Progenitor Cells from Neonatal Mouse Liver Naoki Tanimizu 3. Identification and Isolation of Clonogenic Cholangiocyte in Mouse Bin Li, Craig Dorrell, Pamela S. Canady, and Leslie Wakefield 4. Isolation and Expansion of Rat Hepatocytic Progenitor Cells Junichi Kino, Norihisa Ichinohe, Masayuki Ishii, and Toshihiro Mitaka Part II Characterization of Liver Progenitors In Vivo 5. Genetic Lineage Tracing of Biliary Epithelial Cells Teresa Rubio-Tomás, Beatriz Aguilar-Bravo, and Pau Sancho-Bru 6. Specific Labeling and Lineage Tracing of Periportal Hepatocytes Using Two-Step Genetic Recombination Nicola de Prisco, Eleanor Stout, and Joan Fong-Burgada 7. Analysis for the Heterogeneity of Liver Progenitor Cells Kenji Kamimoto 8. Chemical Screening Using a Zebrafish Model for Liver Progenitor Cell-Driven Liver Regeneration Sungjin Ko and Donghun Shin Part III Generation of Hepatocytes, Cholangiocytes, and Their Progenitors 9. Conversion of Fibroblasts to Hepatocytes In Vitro Pengyu Huang, Lulu Sun, Ludi Zhang, and Lijian Hui 10. Conversion of Fibroblasts to Hepatocyte-Like Cells In Vivo Guangqi Song, Qinggong Yuan, Zhen Dai, Hsin-Chieh Tsay, Xizhong Shen, Michael Ott, and Amar Deep Sharma 11. Chemically Induced Liver Progenitors (CLiPs): A Novel Cell Source for Hepatocytes and Biliary Epithelial Cells Takeshi Katsuda and Takahiro Ochiya 12. Induction of Functional Hepatocytes from Human iPSCs Taketomo Kido and Yuta Koui 13. Culture System of Bile Duct-Like Cystic Structures Derived from Human Inducible Pluripotent Stem Cells Akihide Kamiya, Kazuya Anzai, Kota Tsuruya, and Hiromi Chikada Part IV Reconstitution of Liver Tissue Structures 14. Generation of Hepatic Tissue Structures Using Multicellular Spheroid Culture Fumiya Tao, Hirotaka Mihara, and Nobuhiko Kojima 15. Reconstruction of Hepatic Tissue Structures Using Interstitial Flow in a Microfluidic Device Ryo Sudo 16. Generation of Hepatic Organoids with Biliary Structures Takeshi Katsuda, Takahiro Ochiya, and Yasuyuki Sakai 17. Analysis for Remodeling Hepatic Tissue Structures in 3D during Regeneration Kota Kaneko Part V Liver Injury Models 18. Canine Liver Fibrosis Model to Assess the Functions of Infused Autologous Bone Marrow-Derived Cells Taro Takami, Kenji Tani, Yasuho Taura, and Isao Sakaida 19. A Rodent Model for Cell Transplantation of Hepatic Progenitor Cells Sei Kakinuma and Akihide Kamiya 20. Mouse Model for Hepatocellular Carcinoma and Cholangiocarcinoma Originated from Mature Hepatocytes Masahiro Yamamoto, Bing Xin, and Yuji Nishikawa 21. Mouse Model for Cholangiocarcinoma from Peribiliary Glands Hayato Nakagawa, Nobumi Suzuki, and Kazuhiko Koike