PART ONE: Strategies & Resistance Comparison of Anti-Ectoparasite and Anti-Endoparasite Therapies and Control Strategies Vaccination Against Ticks Blocking Transmission in Vector-borne Diseases The Threat and Reality of Drug Resistance in Cattle Tick Rhipicephalus (Boophilus) microplus Monitoring Drug Sensitivity in Cattle Ticks New Developments in the Control of Human Lice PART TWO: Screens & Models Molecular Targets to Impair Blood Meal Processing in Ticks Whole-organism Screens for Ectoparasites In vitro Feeding Methods for Hematophagus Arthropods and Their Application in Drug Discovery Testing in Laboratory Animal Models for Ectoparasiticide Discovery and Development Testing in Target Hosts for Ectoparasiticide Discovery and Development PART THREE: Isoxazolines Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites The Discovery of Afoxolaner: A New Ectoparasiticide for Dogs Development of Afoxolaner as a New Ectoparasiticide for Dogs Discovery, Development, and Commercialization of Sarolaner (Simparica®), A Novel Oral Isoxazoline Ectoparasiticide for Dogs Isoxazolines: Preeminent Ectoparasiticides of the Early Twenty-first Century leírás elrejtése